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Inhibition of wild-type p53-expressing AML by novel small molecule HDM2 inhibitor, CGM097
The tumor suppressor, p53, is a key regulator of apoptosis and functions upstream in the apoptotic cascade by both indirectly and directly regulating Bcl-2 family proteins. In cells expressing wild-type (wt) p53, the HDM2 protein binds to p53 and blocks its activity. Inhibition of HDM2:p53 interacti...
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Foilsithe in: | Mol Cancer Ther |
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Main Authors: | , , , , , , , , , , , , , , , , , , , , |
Formáid: | Artigo |
Teanga: | Inglês |
Foilsithe: |
2015
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Ábhair: | |
Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4596780/ https://ncbi.nlm.nih.gov/pubmed/26206331 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-15-0429 |
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