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Tracer-based estimates of protein flux in cases of incomplete product renewal: evidence and implications of heterogeneity in collagen turnover

The synthesis of various molecules can be estimated by measuring the incorporation of a labeled precursor into a product of interest. Unfortunately, a central problem in many studies has been an inability to estimate the intracellular dilution of the precursor and therein correctly calculate the syn...

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Pubblicato in:Am J Physiol Endocrinol Metab
Autori principali: Zhou, Haihong, Wang, Sheng-Ping, Herath, Kithsiri, Kasumov, Takhar, Sadygov, Rovshan G., Previs, Stephen F., Kelley, David E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4596733/
https://ncbi.nlm.nih.gov/pubmed/26015435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00435.2014
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