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Attenuation of lithium-induced natriuresis and kaliuresis in P2Y(2) receptor knockout mice

Whole body knockout (KO) of the P2Y(2) receptor (P2Y(2)R) results in enhanced vasopressin V2 receptor activity and increased renal Na(+) conservation. We hypothesized that P2Y(2)R KO mice would be less sensitive to lithium-induced natriuresis and kaliuresis due to attenuated downregulation of one or...

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Bibliografski detalji
Izdano u:Am J Physiol Renal Physiol
Glavni autori: Zhang, Yue, Li, Lijun, Kohan, Donald E., Ecelbarger, Carolyn M., Kishore, Bellamkonda K.
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4596727/
https://ncbi.nlm.nih.gov/pubmed/23739592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00464.2012
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