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De novo assembly and next-generation sequencing to analyse full-length gene variants from codon-barcoded libraries

Interpreting epistatic interactions is crucial for understanding evolutionary dynamics of complex genetic systems and unveiling structure and function of genetic pathways. Although high resolution mapping of en masse variant libraries renders molecular biologists to address genotype-phenotype relati...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Cho, Namjin, Hwang, Byungjin, Yoon, Jung-ki, Park, Sangun, Lee, Joongoo, Seo, Han Na, Lee, Jeewon, Huh, Sunghoon, Chung, Jinsoo, Bang, Duhee
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4595759/
https://ncbi.nlm.nih.gov/pubmed/26387459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9351
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