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De novo assembly and next-generation sequencing to analyse full-length gene variants from codon-barcoded libraries

Interpreting epistatic interactions is crucial for understanding evolutionary dynamics of complex genetic systems and unveiling structure and function of genetic pathways. Although high resolution mapping of en masse variant libraries renders molecular biologists to address genotype-phenotype relati...

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Dettagli Bibliografici
Pubblicato in:Nat Commun
Autori principali: Cho, Namjin, Hwang, Byungjin, Yoon, Jung-ki, Park, Sangun, Lee, Joongoo, Seo, Han Na, Lee, Jeewon, Huh, Sunghoon, Chung, Jinsoo, Bang, Duhee
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Pub. Group 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4595759/
https://ncbi.nlm.nih.gov/pubmed/26387459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9351
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