eIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription

Insulin regulates glycaemia, lipogenesis and increases mRNA translation. Cells with reduced eukaryotic initiation factor 6 (eIF6) do not increase translation in response to insulin. The role of insulin-regulated translation is unknown. Here we show that reduction of insulin-regulated translation in...

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Udgivet i:Nat Commun
Main Authors: Brina, Daniela, Miluzio, Annarita, Ricciardi, Sara, Clarke, Kim, Davidsen, Peter K., Viero, Gabriella, Tebaldi, Toma, Offenhäuser, Nina, Rozman, Jan, Rathkolb, Birgit, Neschen, Susanne, Klingenspor, Martin, Wolf, Eckhard, Gailus-Durner, Valerie, Fuchs, Helmut, Hrabe de Angelis, Martin, Quattrone, Alessandro, Falciani, Francesco, Biffo, Stefano
Format: Artigo
Sprog:Inglês
Udgivet: Nature Pub. Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4595657/
https://ncbi.nlm.nih.gov/pubmed/26383020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9261
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