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Structure-Activity Relationship of N,N′-Disubstituted Pyrimidinetriones as Ca(V)1.3 Calcium Channel-Selective Antagonists for Parkinson’s Disease
Ca(V)1.3 L-type calcium channels (LTCCs) have been a potential target for Parkinson’s disease since calcium ion influx through the channel was implicated in the generation of mitochondrial oxidative stress, causing cell death in the dopaminergic neurons. Selective inhibition of Ca(V)1.3 over other L...
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| Publicado no: | J Med Chem |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4595045/ https://ncbi.nlm.nih.gov/pubmed/23651412 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm4005048 |
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