Synthesis of Long-Circulating, Backbone Degradable HPMA Copolymer–Doxorubicin Conjugates and Evaluation of Molecular-Weight-Dependent Antitumor Efficacy()

Backbone degradable, linear, multiblock N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer–doxorubicin (DOX) conjugates are synthesized by reversible addition–fragmentation chain transfer (RAFT) polymerization followed by chain extension via thiol-ene click reaction. The examination of molecular-wei...

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Publicado en:Macromol Biosci
Main Authors: Pan, Huaizhong, Sima, Monika, Yang, Jiyuan, Kopeček, Jindřich
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4595041/
https://ncbi.nlm.nih.gov/pubmed/23339052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mabi.201200353
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