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Beyond Standard Therapy: Drugs Under Investigation for The Treatment of Gastrointestinal Stromal Tumor

INTRODUCTION: Gastrointestinal stromal tumor (GIST) is the most common non-epithelial malignancy of the GI tract. With the discovery of KIT and later PDGFRA gain-of-function mutations as factors in the pathogenesis of the disease, GIST was the quintessential model for targeted therapy. Despite the s...

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Pubblicato in:Expert Opin Investig Drugs
Autori principali: Alturkmani, Hani J, Pessetto, Ziyan Y, Godwin, Andrew K
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4594857/
https://ncbi.nlm.nih.gov/pubmed/26098203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1517/13543784.2015.1046594
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