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Anti-HA glycoforms drive B cell affinity selection and determine influenza vaccine efficacy
Protective vaccines elicit high affinity, neutralizing antibodies by selection of somatically hypermutated B-cell antigen receptors (BCR) on immune complexes (ICs). This implicates Fc-Fc receptor (FcR) interactions in affinity maturation, which, in turn, are determined by IgG subclass and Fc glycan...
Kaydedildi:
| Yayımlandı: | Cell |
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| Asıl Yazarlar: | , , , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2015
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4594835/ https://ncbi.nlm.nih.gov/pubmed/26140596 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.06.026 |
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