Anti-HA glycoforms drive B cell affinity selection and determine influenza vaccine efficacy

Protective vaccines elicit high affinity, neutralizing antibodies by selection of somatically hypermutated B-cell antigen receptors (BCR) on immune complexes (ICs). This implicates Fc-Fc receptor (FcR) interactions in affinity maturation, which, in turn, are determined by IgG subclass and Fc glycan...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Cell
Main Authors: Wang, Taia T., Maamary, Jad, Tan, Gene S., Bournazos, Stylianos, Davis, Carl W., Krammer, Florian, Schlesinger, Sarah J., Palese, Peter, Ahmed, Rafi, Ravetch, Jeffrey V.
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4594835/
https://ncbi.nlm.nih.gov/pubmed/26140596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.06.026
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki