Anti-HA glycoforms drive B cell affinity selection and determine influenza vaccine efficacy

Protective vaccines elicit high affinity, neutralizing antibodies by selection of somatically hypermutated B-cell antigen receptors (BCR) on immune complexes (ICs). This implicates Fc-Fc receptor (FcR) interactions in affinity maturation, which, in turn, are determined by IgG subclass and Fc glycan...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Wang, Taia T., Maamary, Jad, Tan, Gene S., Bournazos, Stylianos, Davis, Carl W., Krammer, Florian, Schlesinger, Sarah J., Palese, Peter, Ahmed, Rafi, Ravetch, Jeffrey V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4594835/
https://ncbi.nlm.nih.gov/pubmed/26140596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.06.026
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