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CDC4/FBXW7 and the ‘just enough’ model of tumourigenesis
There is good evidence to show that cancer-causing mutations are not always simple gain- and loss-of-function changes. One example is the APC gene, where the combination of mutations produces a ‘just-right’ level of Wnt signalling. A recent article by Berger and colleagues posited a ‘continuum model...
Sparad:
| I publikationen: | J Pathol |
|---|---|
| Huvudupphovsmän: | , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2012
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4594772/ https://ncbi.nlm.nih.gov/pubmed/22323043 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.4004 |
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