Population pharmacokinetic analysis of tacrolimus in Mexican paediatric renal transplant patients: role of CYP3A5 genotype and formulation

AIMS: The aims of this study were (i) to develop a population pharmacokinetic (PK) model of tacrolimus in a Mexican renal transplant paediatric population (n = 53) and (ii) to test the influence of different covariates on its PK properties to facilitate dose individualization. METHODS: Population PK...

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Bibliographische Detailangaben
Veröffentlicht in:Br J Clin Pharmacol
Hauptverfasser: Jacobo-Cabral, Carlos Orlando, García-Roca, Pilar, Romero-Tejeda, Elba Margarita, Reyes, Herlinda, Medeiros, Mara, Castañeda-Hernández, Gilberto, Trocóniz, Iñaki F
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley & Sons, Ltd 2015
Schlagworte:
Pharmacokinetics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4594699/
https://ncbi.nlm.nih.gov/pubmed/25846845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12649
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