Lack of tacrolimus circadian pharmacokinetics and CYP3A5 pharmacogenetics in the early and maintenance stages in Japanese renal transplant recipients

AIMS: We investigated whether tacrolimus pharmacokinetics shows circadian variation and the influence of the CYP3A5 A6986G polymorphism on the pharmacokinetics in both the early and maintenance stages after renal transplantation. METHODS: Tacrolimus was administered twice daily at specified times (0...

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Hauptverfasser: Satoh, Shigeru, Kagaya, Hideaki, Saito, Mitsuru, Inoue, Takamitsu, Miura, Masatomo, Inoue, Kazuyuki, Numakura, Kazuyuki, Tsuchiya, Norihiko, Tada, Hitoshi, Suzuki, Toshio, Habuchi, Tomonori
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Science Inc 2008
Schlagworte:
Pharmacokinetics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2492917/
https://ncbi.nlm.nih.gov/pubmed/18429967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2008.03188.x
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