Insights into the structural nature of the transition state in the Kir channel gating pathway

In a previous study we identified an extensive gating network within the inwardly rectifying Kir1.1 (ROMK) channel by combining systematic scanning mutagenesis and functional analysis with structural models of the channel in the closed, pre-open and open states. This extensive network appeared to st...

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Publicado en:Channels (Austin)
Autores principales: Fowler, Philip W, Bollepalli, Murali K, Rapedius, Markus, Nematian-Ardestani, Ehsan, Shang, Lijun, Sansom, Mark SP, Tucker, Stephen J, Baukrowitz, Thomas
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2014
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Article Addenda
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4594414/
https://ncbi.nlm.nih.gov/pubmed/25483285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/19336950.2014.962371
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