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Influence of lipids on the hydrophobic barrier within the pore of the TWIK-1 K2P channel

Several recent ion channel structures have revealed large side portals, or ‘fenestrations’ at the interface between their transmembrane helices that potentially expose the ion conduction pathway to the lipid core of the bilayer. In a recent study we demonstrated that functional activity of the TWIK-...

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Détails bibliographiques
Publié dans:Channels (Austin)
Auteurs principaux: Aryal, Prafulla, Abd-Wahab, Firdaus, Bucci, Giovanna, Sansom, Mark SP, Tucker, Stephen J
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4594343/
https://ncbi.nlm.nih.gov/pubmed/25487004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/19336950.2014.981987
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