Protocadherin-1 binds to SMAD3 and suppresses TGF-β1-induced gene transcription

Genetic studies have identified Protocadherin-1 (PCDH1) and Mothers against decapentaplegic homolog-3 (SMAD3) as susceptibility genes for asthma. PCDH1 is expressed in bronchial epithelial cells and has been found to interact with SMAD3 in yeast two-hybrid (Y2H) overexpression assays. Here, we test...

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Detalhes bibliográficos
Publicado no:Am J Physiol Lung Cell Mol Physiol
Main Authors: Faura Tellez, Grissel, Vandepoele, Karl, Brouwer, Uilke, Koning, Henk, Elderman, Robin M., Hackett, Tillie-Louise, Willemse, Brigitte W. M., Holloway, John, Van Roy, Frans, Koppelman, Gerard H., Nawijn, Martijn C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4593836/
https://ncbi.nlm.nih.gov/pubmed/26209277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00346.2014
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