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ACE2 deficiency reduces β-cell mass and impairs β-cell proliferation in obese C57BL/6 mice

Drugs that inhibit the renin-angiotensin system (RAS) decrease the onset of type 2 diabetes (T2D). Pancreatic islets express RAS components, including angiotensin-converting enzyme 2 (ACE2), which cleaves angiotensin II (Ang II) to angiotensin-(1–7) [Ang-(1–7)]. Overexpression of ACE2 in pancreas of...

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Bibliografische gegevens
Gepubliceerd in:Am J Physiol Endocrinol Metab
Hoofdauteurs: Shoemaker, Robin, Yiannikouris, Frederique, Thatcher, Sean, Cassis, Lisa
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Physiological Society 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4593774/
https://ncbi.nlm.nih.gov/pubmed/26389599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00054.2015
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