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ACE2 deficiency reduces β-cell mass and impairs β-cell proliferation in obese C57BL/6 mice
Drugs that inhibit the renin-angiotensin system (RAS) decrease the onset of type 2 diabetes (T2D). Pancreatic islets express RAS components, including angiotensin-converting enzyme 2 (ACE2), which cleaves angiotensin II (Ang II) to angiotensin-(1–7) [Ang-(1–7)]. Overexpression of ACE2 in pancreas of...
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| Udgivet i: | Am J Physiol Endocrinol Metab |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Physiological Society
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4593774/ https://ncbi.nlm.nih.gov/pubmed/26389599 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00054.2015 |
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