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Weighted Score Tests Implementing Model-Averaging Schemes in Detection of Rare Variants in Case-Control Studies

Multi-locus effect modeling is a powerful approach for detection of genes influencing a complex disease. Especially for rare variants, we need to analyze multiple variants together to achieve adequate power for detection. In this paper, we propose several parsimonious branching model techniques to a...

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Dades bibliogràfiques
Publicat a:PLoS One
Autors principals: Coombes, Brandon, Basu, Saonli, Guha, Sharmistha, Schork, Nicholas
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4593572/
https://ncbi.nlm.nih.gov/pubmed/26436424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0139355
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