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Weighted Score Tests Implementing Model-Averaging Schemes in Detection of Rare Variants in Case-Control Studies

Multi-locus effect modeling is a powerful approach for detection of genes influencing a complex disease. Especially for rare variants, we need to analyze multiple variants together to achieve adequate power for detection. In this paper, we propose several parsimonious branching model techniques to a...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Coombes, Brandon, Basu, Saonli, Guha, Sharmistha, Schork, Nicholas
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4593572/
https://ncbi.nlm.nih.gov/pubmed/26436424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0139355
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