Discovery of phosphonic acid natural products by mining the genomes of 10,000 actinomycetes

Although natural products have been a particularly rich source of human medicines, activity-based screening results in a very high rate of rediscovery of known molecules. Based on the large number of natural product biosynthetic genes in microbial genomes, many have proposed “genome mining” as an al...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Ju, Kou-San, Gao, Jiangtao, Doroghazi, James R., Wang, Kwo-Kwang A., Thibodeaux, Christopher J., Li, Steven, Metzger, Emily, Fudala, John, Su, Joleen, Zhang, Jun Kai, Lee, Jaeheon, Cioni, Joel P., Evans, Bradley S., Hirota, Ryuichi, Labeda, David P., van der Donk, Wilfred A., Metcalf, William W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2015
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4593130/
https://ncbi.nlm.nih.gov/pubmed/26324907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1500873112
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