Discovery of phosphonic acid natural products by mining the genomes of 10,000 actinomycetes

Although natural products have been a particularly rich source of human medicines, activity-based screening results in a very high rate of rediscovery of known molecules. Based on the large number of natural product biosynthetic genes in microbial genomes, many have proposed “genome mining” as an al...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Ju, Kou-San, Gao, Jiangtao, Doroghazi, James R., Wang, Kwo-Kwang A., Thibodeaux, Christopher J., Li, Steven, Metzger, Emily, Fudala, John, Su, Joleen, Zhang, Jun Kai, Lee, Jaeheon, Cioni, Joel P., Evans, Bradley S., Hirota, Ryuichi, Labeda, David P., van der Donk, Wilfred A., Metcalf, William W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4593130/
https://ncbi.nlm.nih.gov/pubmed/26324907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1500873112
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