Amelioration of inflammation and tissue damage in sickle cell model mice by Nrf2 activation

Sickle cell disease (SCD) is an inherited disorder caused by a point mutation in the β-globin gene, leading to the production of abnormally shaped red blood cells. Sickle cells are prone to hemolysis and thereby release free heme into plasma, causing oxidative stress and inflammation that in turn re...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Keleku-Lukwete, Nadine, Suzuki, Mikiko, Otsuki, Akihito, Tsuchida, Kouhei, Katayama, Saori, Hayashi, Makiko, Naganuma, Eriko, Moriguchi, Takashi, Tanabe, Osamu, Engel, James Douglas, Imaizumi, Masue, Yamamoto, Masayuki
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2015
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4593117/
https://ncbi.nlm.nih.gov/pubmed/26371321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1509158112
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