Amelioration of inflammation and tissue damage in sickle cell model mice by Nrf2 activation

Sickle cell disease (SCD) is an inherited disorder caused by a point mutation in the β-globin gene, leading to the production of abnormally shaped red blood cells. Sickle cells are prone to hemolysis and thereby release free heme into plasma, causing oxidative stress and inflammation that in turn re...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Keleku-Lukwete, Nadine, Suzuki, Mikiko, Otsuki, Akihito, Tsuchida, Kouhei, Katayama, Saori, Hayashi, Makiko, Naganuma, Eriko, Moriguchi, Takashi, Tanabe, Osamu, Engel, James Douglas, Imaizumi, Masue, Yamamoto, Masayuki
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4593117/
https://ncbi.nlm.nih.gov/pubmed/26371321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1509158112
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