Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis

NCOA4 is a selective cargo receptor for the autophagic turnover of ferritin, a process critical for regulation of intracellular iron bioavailability. However, how ferritinophagy flux is controlled and the roles of NCOA4 in iron-dependent processes are poorly understood. Through analysis of the NCOA4...

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Veröffentlicht in:eLife
Hauptverfasser: Mancias, Joseph D, Pontano Vaites, Laura, Nissim, Sahar, Biancur, Douglas E, Kim, Andrew J, Wang, Xiaoxu, Liu, Yu, Goessling, Wolfram, Kimmelman, Alec C, Harper, J Wade
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2015
Schlagworte:
Cell Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4592949/
https://ncbi.nlm.nih.gov/pubmed/26436293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.10308
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