BAD Is a Pro-survival Factor Prior to Activation of Its Pro-apoptotic Function

The mammalian BAD protein belongs to the BH3-only subgroup of the BCL-2 family. In contrast to its known pro-apoptotic function, we found that endogenous and overexpressed BAD(L) can inhibit cell death in neurons and other cell types. Several mechanisms regulate the conversion of BAD from an anti-de...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Seo, So Young, Chen, Ying-bei, Ivanovska, Iva, Ranger, Ann M., Hong, Suk J., Dawson, Valina L., Korsmeyer, Stanley J., Bellows, David S., Fannjiang, Yihru, Hardwick, J. Marie
Format: Artigo
Sprog:Inglês
Udgivet: 2004
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4591964/
https://ncbi.nlm.nih.gov/pubmed/15231831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M406775200
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