Inhibition of Oncogenic Epidermal Growth Factor Receptor Kinase Triggers Release of Exosome-like Extracellular Vesicles and Impacts Their Phosphoprotein and DNA Content

Cancer cells emit extracellular vesicles (EVs) containing unique molecular signatures. Here, we report that the oncogenic EGF receptor (EGFR) and its inhibitors reprogram phosphoproteomes and cargo of tumor cell-derived EVs. Thus, phosphorylated EGFR (P-EGFR) and several other receptor tyrosine kina...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Montermini, Laura, Meehan, Brian, Garnier, Delphine, Lee, Wan Jin, Lee, Tae Hoon, Guha, Abhijit, Al-Nedawi, Khalid, Rak, Janusz
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4591833/
https://ncbi.nlm.nih.gov/pubmed/26272609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.679217
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