Inhibition of Oncogenic Epidermal Growth Factor Receptor Kinase Triggers Release of Exosome-like Extracellular Vesicles and Impacts Their Phosphoprotein and DNA Content

Cancer cells emit extracellular vesicles (EVs) containing unique molecular signatures. Here, we report that the oncogenic EGF receptor (EGFR) and its inhibitors reprogram phosphoproteomes and cargo of tumor cell-derived EVs. Thus, phosphorylated EGFR (P-EGFR) and several other receptor tyrosine kina...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Biol Chem
Päätekijät: Montermini, Laura, Meehan, Brian, Garnier, Delphine, Lee, Wan Jin, Lee, Tae Hoon, Guha, Abhijit, Al-Nedawi, Khalid, Rak, Janusz
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2015
Aiheet:
Molecular Bases of Disease
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4591833/
https://ncbi.nlm.nih.gov/pubmed/26272609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.679217
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