Inhibition of Oncogenic Epidermal Growth Factor Receptor Kinase Triggers Release of Exosome-like Extracellular Vesicles and Impacts Their Phosphoprotein and DNA Content

Cancer cells emit extracellular vesicles (EVs) containing unique molecular signatures. Here, we report that the oncogenic EGF receptor (EGFR) and its inhibitors reprogram phosphoproteomes and cargo of tumor cell-derived EVs. Thus, phosphorylated EGFR (P-EGFR) and several other receptor tyrosine kina...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Montermini, Laura, Meehan, Brian, Garnier, Delphine, Lee, Wan Jin, Lee, Tae Hoon, Guha, Abhijit, Al-Nedawi, Khalid, Rak, Janusz
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2015
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4591833/
https://ncbi.nlm.nih.gov/pubmed/26272609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.679217
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