Microprocessor Complex Subunit DiGeorge Syndrome Critical Region Gene 8 (Dgcr8) Is Required for Schwann Cell Myelination and Myelin Maintenance

We investigated the role of a key component of the Microprocessor complex, DGCR8, in the regulation of myelin formation and maintenance. We found that conditionally ablating Dgcr8 in Schwann cells (SCs) during development results in an arrest of SC differentiation. Dgcr8 conditional knock-out (cKO)...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Lin, Hsin-Pin, Oksuz, Idil, Hurley, Edward, Wrabetz, Lawrence, Awatramani, Rajeshwar
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
Neurobiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4591815/
https://ncbi.nlm.nih.gov/pubmed/26272614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.636407
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