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SUMOylation-disrupting WAS mutation converts WASp from a transcriptional activator to a repressor of NF-κB response genes in T cells
In Wiskott-Aldrich syndrome (WAS), immunodeficiency and autoimmunity often comanifest, yet how WAS mutations misregulate chromatin-signaling in T(helper) (T(H)) cells favoring development of auto-inflammation over protective immunity is unclear. Previously, we identified an essential promoter-specif...
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| Publicado no: | Blood |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4591791/ https://ncbi.nlm.nih.gov/pubmed/26261240 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-05-646182 |
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