Attenuated sarcomere lengthening of the aged murine left ventricle observed using two-photon fluorescence microscopy

The Frank-Starling mechanism, whereby increased diastolic filling leads to increased cardiac output, depends on increasing the sarcomere length (L(s)) of cardiomyocytes. Ventricular stiffness increases with advancing age, yet it remains unclear how such changes in compliance impact sarcomere dynamic...

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Detalhes bibliográficos
Publicado no:Am J Physiol Heart Circ Physiol
Main Authors: Nance, Michael E., Whitfield, Justin T., Zhu, Yi, Gibson, Anne K., Hanft, Laurin M., Campbell, Kenneth S., Meininger, Gerald A., McDonald, Kerry S., Segal, Steven S., Domeier, Timothy L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2015
Assuntos:
Muscle Mechanics and Ventricular Function
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4591408/
https://ncbi.nlm.nih.gov/pubmed/26209054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00315.2015
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