Dantrolene suppresses spontaneous Ca(2+) release without altering excitation-contraction coupling in cardiomyocytes of aged mice

Cardiac dysfunction in the aged heart reflects abnormalities in cardiomyocyte Ca(2+) homeostasis including altered Ca(2+) cycling through the sarcoplasmic reticulum (SR). The ryanodine receptor antagonist dantrolene exerts antiarrhythmic effects by preventing spontaneous diastolic Ca(2+) release fro...

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Main Authors: Domeier, Timothy L., Roberts, Cale J., Gibson, Anne K., Hanft, Laurin M., McDonald, Kerry S., Segal, Steven S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2014
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Call for Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4166750/
https://ncbi.nlm.nih.gov/pubmed/25038147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00287.2014
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