PD98059 Influences Immune Factors and Enhances Opioid Analgesia in Model of Neuropathy

Neuropathic pain treatment remains challenging due to ineffective therapy and resistance to opioid analgesia. Mitogen-activated protein kinase kinase (MAPKK) have been identified as the crucial regulators of pro- and antinociceptive factors. We used PD98059, an inhibitor of the MAPKK family members...

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Publicado en:PLoS One
Autores principales: Rojewska, Ewelina, Popiolek-Barczyk, Katarzyna, Kolosowska, Natalia, Piotrowska, Anna, Zychowska, Magdalena, Makuch, Wioletta, Przewlocka, Barbara, Mika, Joanna
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2015
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4591269/
https://ncbi.nlm.nih.gov/pubmed/26426693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0138583
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