Aberrant ORM (yeast)–like protein isoform 3 (ORMDL3) expression dysregulates ceramide homeostasis in cells and ceramide exacerbates allergic asthma in mice

BACKGROUND: Asthma, a chronic inflammatory condition defined by episodic shortness of breath with expiratory wheezing and cough, is a serious health concern affecting more than 250 million persons. Genome-wide association studies have identified ORM (yeast)–like protein isoform 3 (ORMDL3) as a gene...

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Pubblicato in:J Allergy Clin Immunol
Autori principali: Oyeniran, Clement, Sturgill, Jamie L., Hait, Nitai C., Huang, Wei-Ching, Avni, Dorit, Maceyka, Michael, Newton, Jason, Allegood, Jeremy C., Montpetit, Alison, Conrad, Daniel H., Milstien, Sheldon, Spiegel, Sarah
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4591101/
https://ncbi.nlm.nih.gov/pubmed/25842287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2015.02.031
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