Role of sphingosine kinase 1 and sphingosine-1-phosphate in CD40 signaling and IgE class switching

The tumor necrosis factor (TNF) receptor family member CD40 plays an essential role in the activation of antigen-presenting cells, B cell maturation, and immunoglobulin (Ig) class switching critical for adaptive immunity. Although the bioactive sphingolipid metabolite sphingosine-1-phosphate (S1P) a...

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Detalhes bibliográficos
Main Authors: Kim, Eugene Y., Sturgill, Jamie L., Hait, Nitai C., Avni, Dorit, Valencia, Evelyn C., Maceyka, Michael, Lima, Santiago, Allegood, Jeremy, Huang, Wei-Ching, Zhang, Shijun, Milstien, Sheldon, Conrad, Daniel, Spiegel, Sarah
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2014
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4202100/
https://ncbi.nlm.nih.gov/pubmed/25002116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.14-251611
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