Phenylbutyrate induces LL-37-dependent autophagy and intracellular killing of Mycobacterium tuberculosis in human macrophages

LL-37 is a human antimicrobial peptide (AMP) of the cathelicidin family with multiple activities including a mediator of vitamin D-induced autophagy in human macrophages, resulting in intracellular killing of Mycobacterium tuberculosis (Mtb). In a previous trial in healthy volunteers, we have shown...

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Bibliographic Details
Published in:Autophagy
Main Authors: Rekha, Rokeya Sultana, Rao Muvva, SSV Jagadeeswara, Wan, Min, Raqib, Rubhana, Bergman, Peter, Brighenti, Susanna, Gudmundsson, Gudmundur H, Agerberth, Birgitta
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2015
Subjects:
Translational Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4590658/
https://ncbi.nlm.nih.gov/pubmed/26218841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2015.1075110
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