Oral intake of phenylbutyrate with or without vitamin D(3) upregulates the cathelicidin LL-37 in human macrophages: a dose finding study for treatment of tuberculosis

BACKGROUND: We earlier showed that 4-phenylbutyrate (PB) can induce cathelicidin LL-37 expression synergistically with 1,25-dihydroxyvitamin D(3) in a lung epithelial cell line. We aimed to evaluate a therapeutic dose of PB alone or in combination with vitamin D(3) for induction of LL-37 expression...

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Главные авторы: Mily, Akhirunnesa, Rekha, Rokeya Sultana, Kamal, S M Mostafa, Akhtar, Evana, Sarker, Protim, Rahim, Zeaur, Gudmundsson, Gudmundur H, Agerberth, Birgitta, Raqib, Rubhana
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2013
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3637063/
https://ncbi.nlm.nih.gov/pubmed/23590701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2466-13-23
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