Phenylbutyrate Counteracts Shigella Mediated Downregulation of Cathelicidin in Rabbit Lung and Intestinal Epithelia: A Potential Therapeutic Strategy

BACKGROUND: Cathelicidins and defensins are endogenous antimicrobial peptides (AMPs) that are downregulated in the mucosal epithelia of the large intestine in shigellosis. Oral treatment of Shigella infected rabbits with sodium butyrate (NaB) reduces clinical severity and counteracts the downregulat...

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Main Authors: Sarker, Protim, Ahmed, Sultan, Tiash, Snigdha, Rekha, Rokeya Sultana, Stromberg, Roger, Andersson, Jan, Bergman, Peter, Gudmundsson, Gudmundur H., Agerberth, Birgitta, Raqib, Rubhana
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3108617/
https://ncbi.nlm.nih.gov/pubmed/21673991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0020637
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