Phenylbutyrate Counteracts Shigella Mediated Downregulation of Cathelicidin in Rabbit Lung and Intestinal Epithelia: A Potential Therapeutic Strategy

BACKGROUND: Cathelicidins and defensins are endogenous antimicrobial peptides (AMPs) that are downregulated in the mucosal epithelia of the large intestine in shigellosis. Oral treatment of Shigella infected rabbits with sodium butyrate (NaB) reduces clinical severity and counteracts the downregulat...

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Asıl Yazarlar: Sarker, Protim, Ahmed, Sultan, Tiash, Snigdha, Rekha, Rokeya Sultana, Stromberg, Roger, Andersson, Jan, Bergman, Peter, Gudmundsson, Gudmundur H., Agerberth, Birgitta, Raqib, Rubhana
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2011
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3108617/
https://ncbi.nlm.nih.gov/pubmed/21673991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0020637
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