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Establishment of a selective evaluation method for DPP4 inhibitors based on recombinant human DPP8 and DPP9 proteins

Dipeptidyl peptidase 4 (DPP4) is recognised as an attractive anti-diabetic drug target, and several DPP4 inhibitors are already on the market. As members of the same gene family, dipeptidyl peptidase 8 (DPP8) and dipeptidyl peptidase 9 (DPP9) share high sequence and structural homology as well as fu...

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Foilsithe in:Acta Pharm Sin B
Main Authors: Liu, Jinglong, Huan, Yi, Li, Caina, Liu, Minzhi, Shen, Zhufang
Formáid: Artigo
Teanga:Inglês
Foilsithe: Elsevier 2014
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4590293/
https://ncbi.nlm.nih.gov/pubmed/26579375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2013.12.007
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