Cancer-related CD15/FUT4 overexpression decreases benefit to agents targeting EGFR or VEGF acting as a novel RAF-MEK-ERK kinase downstream regulator in metastatic colorectal cancer

BACKGROUND: Cancer-related immune antigens in the tumor microenvironment could represent an obstacle to agents targeting EGFR “cetuximab” or VEGF “bevacizumab” in metastatic colorectal cancer (mCRC) patients. METHODS: Infiltrating immune cells into tumor tissues, cancer-related expression of immune...

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Pubblicato in:J Exp Clin Cancer Res
Autori principali: Giordano, Guido, Febbraro, Antonio, Tomaselli, Eugenio, Sarnicola, Maria Lucia, Parcesepe, Pietro, Parente, Domenico, Forte, Nicola, Fabozzi, Alessio, Remo, Andrea, Bonetti, Andrea, Manfrin, Erminia, Ghasemi, Somayehsadat, Ceccarelli, Michele, Cerulo, Luigi, Bazzoni, Flavia, Pancione, Massimo
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2015
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4590269/
https://ncbi.nlm.nih.gov/pubmed/26427914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-015-0225-7
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