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Cancer-related CD15/FUT4 overexpression decreases benefit to agents targeting EGFR or VEGF acting as a novel RAF-MEK-ERK kinase downstream regulator in metastatic colorectal cancer
BACKGROUND: Cancer-related immune antigens in the tumor microenvironment could represent an obstacle to agents targeting EGFR “cetuximab” or VEGF “bevacizumab” in metastatic colorectal cancer (mCRC) patients. METHODS: Infiltrating immune cells into tumor tissues, cancer-related expression of immune...
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Published in: | J Exp Clin Cancer Res |
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Main Authors: | , , , , , , , , , , , , , , , |
Format: | Artigo |
Language: | Inglês |
Published: |
BioMed Central
2015
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Subjects: | |
Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4590269/ https://ncbi.nlm.nih.gov/pubmed/26427914 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-015-0225-7 |
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