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A pain-inducing centipede toxin targets the heat activation machinery of nociceptor TRPV1
The capsaicin receptor TRPV1 ion channel is a polymodal nociceptor that responds to heat with exquisite sensitivity through an unknown mechanism. Here we report the identification of a novel toxin, RhTx, from the venom of the Chinese red-headed centipede that potently activates TRPV1 to produce excr...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Pub. Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4589873/ https://ncbi.nlm.nih.gov/pubmed/26420335 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9297 |
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