Regional Isolation Drives Bacterial Diversification within Cystic Fibrosis Lungs

Bacterial lineages that chronically infect cystic fibrosis (CF) patients genetically diversify during infection. However, the mechanisms driving diversification are unknown. By dissecting 10 CF lung pairs and studying ~12,000 regional isolates, we were able to investigate whether clonally-related Ps...

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Veröffentlicht in:Cell Host Microbe
Hauptverfasser: Jorth, Peter, Staudinger, Benjamin J., Wu, Xia, Hisert, Katherine, Hayden, Hillary, Garudathri, Jayanthi, Harding, Christopher, Radey, Matthew C., Rezayat, Amir, Bautista, Gilbert, Barrington, William, Goddard, Amanda F., Zheng, Chunxiang, Angermeyer, Angus, Brittnacher, Mitchell J., Kitzman, Jacob, Shendure, Jay, Fligner, Corinne L., Mittler, John, Aitken, Moira L., Manoil, Colin, Bruce, James E., Yahr, Timothy L., Singh, Pradeep K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4589543/
https://ncbi.nlm.nih.gov/pubmed/26299432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2015.07.006
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