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Identification of Happyhour/MAP4K as alternative Hpo/Mst-like kinases in the Hippo kinase cascade
In Drosophila and mammals, the canonical Hippo kinase cascade is mediated by Hpo/Mst acting through the intermediary kinase Wts/Lats to phosphorylate the transcriptional coactivator Yki/YAP/TAZ. Despite recent reports linking Yki/YAP/TAZ activity to the actin cytoskeleton, the underlying mechanisms...
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| Publicado en: | Dev Cell |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4589524/ https://ncbi.nlm.nih.gov/pubmed/26364751 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2015.08.014 |
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