Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index

We propose a method (GREML-LDMS) to estimate heritability for human complex traits in unrelated individuals using whole-genome sequencing (WGS) data. We demonstrate using simulations based on WGS data that ~97% and ~68% of variation at common and rare variants, respectively, can be captured by imput...

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出版年:Nat Genet
主要な著者: Yang, Jian, Bakshi, Andrew, Zhu, Zhihong, Hemani, Gibran, Vinkhuyzen, Anna A.E., Lee, Sang Hong, Robinson, Matthew R., Perry, John R.B., Nolte, Ilja M., van Vliet-Ostaptchouk, Jana V., Snieder, Harold, Esko, Tonu, Milani, Lili, Mägi, Reedik, Metspalu, Andres, Hamsten, Anders, Magnusson, Patrik K.E., Pedersen, Nancy L., Ingelsson, Erik, Soranzo, Nicole, Keller, Matthew C., Wray, Naomi R., Goddard, Michael E., Visscher, Peter M.
フォーマット: Artigo
言語:Inglês
出版事項: 2015
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4589513/
https://ncbi.nlm.nih.gov/pubmed/26323059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3390
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