Dominance Genetic Variation Contributes Little to the Missing Heritability for Human Complex Traits

For human complex traits, non-additive genetic variation has been invoked to explain “missing heritability,” but its discovery is often neglected in genome-wide association studies. Here we propose a method of using SNP data to partition and estimate the proportion of phenotypic variance attributed...

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Vydáno v:Am J Hum Genet
Hlavní autoři: Zhu, Zhihong, Bakshi, Andrew, Vinkhuyzen, Anna A.E., Hemani, Gibran, Lee, Sang Hong, Nolte, Ilja M., van Vliet-Ostaptchouk, Jana V., Snieder, Harold, Esko, Tonu, Milani, Lili, Mägi, Reedik, Metspalu, Andres, Hill, William G., Weir, Bruce S., Goddard, Michael E., Visscher, Peter M., Yang, Jian
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4375616/
https://ncbi.nlm.nih.gov/pubmed/25683123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2015.01.001
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