Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index

We propose a method (GREML-LDMS) to estimate heritability for human complex traits in unrelated individuals using whole-genome sequencing (WGS) data. We demonstrate using simulations based on WGS data that ~97% and ~68% of variation at common and rare variants, respectively, can be captured by imput...

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Publicado en:Nat Genet
Main Authors: Yang, Jian, Bakshi, Andrew, Zhu, Zhihong, Hemani, Gibran, Vinkhuyzen, Anna A.E., Lee, Sang Hong, Robinson, Matthew R., Perry, John R.B., Nolte, Ilja M., van Vliet-Ostaptchouk, Jana V., Snieder, Harold, Esko, Tonu, Milani, Lili, Mägi, Reedik, Metspalu, Andres, Hamsten, Anders, Magnusson, Patrik K.E., Pedersen, Nancy L., Ingelsson, Erik, Soranzo, Nicole, Keller, Matthew C., Wray, Naomi R., Goddard, Michael E., Visscher, Peter M.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4589513/
https://ncbi.nlm.nih.gov/pubmed/26323059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3390
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