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Specific hepatic delivery of procollagen α1(I) siRNA in lipid-like nanoparticles resolves liver fibrosis
Fibrosis accompanies the wound-healing response to chronic liver injury and is characterized by excessive hepatic collagen accumulation dominated by collagen type I that often progresses to cirrhosis. Here we present ample in-vivo evidence of an up to 90% suppression of procollagen α1(I) expression,...
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| Publicado no: | Hepatology |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4589454/ https://ncbi.nlm.nih.gov/pubmed/26096209 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.27936 |
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